Full-Thickness Macular Hole After Intravitreal Conbercept Injection in Branch Retinal Vein Occlusion.

This article reports a case of macular hole (MH) formation following intravitreal conbercept injection for branch retinal vein occlusion (BRVO). A 70-year-old male received three consecutive intravitreal injections of conbercept for the treatment of macular edema secondary to BRVO in his left eye. Due to the outbreak of the COVID-19 epidemic, the patient was lost to follow-up. At two months follow-up, a full-thickness MH was detected by fundoscopic and optical coherence tomography examination. Fortunately, the MH was successfully closed after pars plana vitrectomy. MH is a rare complication following intravitreal injections for RVO, which should be considered by clinicians.

Drug Repositioning for Hand, Foot, and Mouth Disease.

Hand, foot, and mouth disease (HFMD) is a highly contagious disease in children caused by a group of enteroviruses. HFMD currently presents a major threat to infants and young children because of a lack of antiviral drugs in clinical practice. Drug repositioning is an attractive drug discovery strategy aimed at identifying and developing new drugs for diseases. Notably, repositioning of well-characterized therapeutics, including either approved or investigational drugs, is becoming a potential strategy to identify new treatments for virus infections. Various types of drugs, including antibacterial, cardiovascular, and anticancer agents, have been studied in relation to their therapeutic potential to treat HFMD. In this review, we summarize the major outbreaks of HFMD and the progress in drug repositioning to treat this disease. We also discuss the structural features and mode of action of these repositioned drugs and highlight the opportunities and challenges of drug repositioning for HFMD.

Quantitative analysis of the impact of COVID-19 on ship visiting behaviors to ports- A framework and a case study.

Corona Virus Disease 2019 (COVID-19) outbreak leads to a significant downturn in the global economy and supply chain. In the maritime sector, trade volume slumped by 3.8% in 2020 compared with 2019. To explore the impacts of COVID-19 on ship visiting behaviors, a framework is proposed to analyze the impact of COVID-19 on port traffic using Automatic Identification System (AIS) data. Firstly, a ship travel behavior-based model is proposed to identify the vessel anchoring and berthing. Then, the diversity in vessel anchoring and berthing time are analyzed, reflecting the impact of COVID-19. The port congestion caused by COVID-19 is quantified by accounting for the number of visiting ships and their residence time. Finally, a case study is carried out on vessels in the Beibu Gulf, China, operating from 2019 to 2020. The results show that the average anchoring time and berthing time increase by 62% and 11% for cargo ships and by 112% and 63% for oil tankers after the outbreak of COVID-19 compared with that before COVID-19. And the density of ships increases in the port area in 2020. Accordingly, the relevant improvements and countermeasures are proposed to reduce the adverse impact of the epidemic on the port navigation system. The paper has the potential to provide a reference for port management and improving port navigation efficiency in the post-pandemic era.

A study on level of mental health and influencing factors of medical staff in the makeshift hospital during COVID-19 in Shanghai

Objective　To analyze the mental health status of medical staff in the Fourth Branch of National Convention and Exhibition Center Makeshift Hospital during the COVID-19 epidemic in Shanghai to lay a theoretical foundation for the mental health and psychological intervention of medical staff in COVID-19 and other public health emergencies. Methods　An online questionnaire survey was conducted with the generalized anxiety disorder scale (GAD-7), patient health questionnaire (PHQ-9), and Athens insomnia scale (AIS) before medical staff entering the makeshift hospital and one month later. Results　The detection rates of anxiety, depression and insomnia were 18.4%, 22.1% and 27.0% respectively before entering the makeshift hospital, and 28.8%, 59.3% and 64.2% respectively during the follow-up period one month later. The GAD-7, PHQ-9 and AIS scores of medical staff after working in the makeshift hospital for one month increased significantly compared with those at the baseline period (P<0.01). Female and previous history of using sedative and hypnotic drugs were risk factors for increased depression level among medical staff in the makeshift hospital. Conclusions　The anxiety, depression and insomnia levels of the medical staff in Shanghai increased after working in the makeshift hospital for one month. It is of great significance for the front-line support work to identify the medical staff with serious psychological problems and carry out psychological intervention in the early stage.

Quantitative analysis of the impact of COVID-19 on ship visiting behaviors to ports- A framework and a case study

Corona Virus Disease 2019 (COVID-19) outbreak leads to a significant downturn in the global economy and supply chain. In the maritime sector, trade volume slumped by 3.8% in 2020 compared with 2019. To explore the impacts of COVID-19 on ship visiting behaviors, a framework is proposed to analyze the impact of COVID-19 on port traffic using Automatic Identification System (AIS) data. Firstly, a ship travel behavior-based model is proposed to identify the vessel anchoring and berthing. Then, the diversity in vessel anchoring and berthing time are analyzed, reflecting the impact of COVID-19. The port congestion caused by COVID-19 is quantified by accounting for the number of visiting ships and their residence time. Finally, a case study is carried out on vessels in the Beibu Gulf, China, operating from 2019 to 2020. The results show that the average anchoring time and berthing time increase by 53% and 26% for cargo ships and by 90% and 63% for oil tankers after the outbreak of COVID-19 compared with that before COVID-19. And the density of ships increases in the port area in 2020. Accordingly, the relevant improvements and countermeasures are proposed to reduce the adverse impact of the epidemic on the port navigation system. The paper has the potential to provide a reference for port management and improving port navigation efficiency in the post-pandemic era.

Determining the COVID-19 effects on spillover between oil market and stock exchange: a global perspective analysis.

This paper investigates volatility spillovers between the global crude oil market and the stock markets of the global oil stock markets (Russian, Canada, China, Kuwait, and the USA) pre and after the COVID-19 pandemic. We use wavelet Granger causality methods to study the volatility spillovers between global oil stock markets, mainly from January 1, 2019, to March 31, 2021. Our Results (1) shows that WTI and Brent oil prices had a negative mean return before COVID-19 but a positive mean return during the pandemic spread. Other Results (2) find the positive, significantly lowest, and highest frequency during the COVID-19 outbreak for all selected countries. The results also show that the link between oil WTI & Brent prices and stock markets return in the lowest (33-66 days) and highest frequency range (4-16) before the Covid-19 epidemic, especially in the first quarter of 2020. Before the COVID-19 period, the Russian oil stock market is seriously prejudiced with oil prices on a modest scale, but not after the pandemic's start. This study also perceives direction opposite between the COVID-19 period. The Canadian and United States America oil and stock markets influence the lowest scale in the previous COVID-19 sample for the U.S. market. Moreover, this paper exposed that oil marketing highest oil futures in their portfolios than stock shares for all times. We found that oil price shocks had a more significant impact on the stock markets of the United States and Canada than on the stock markets of other countries.

Improving Public Health and Governance in COVID-19 Response: A Strategic Public Procurement Perspective.

Good governance is the basis of dealing with major emergencies and protecting public health. It has become a major issue of the central government to construct a scientific procurement and supply system of emergency supplies. This article constructs the analytical framework of strategic procurement and expounds the realization mechanism of strategic procurement under an emergency situation to reflect China's procurement practice in COVID-19 response and improve public health and governance. Using case study, semi-structured interviews, and the Nvivo text analysis, this study found that emphasizing the strategic function of securing the public health,the top status of MSG, cross-sector procurement team, strong procurement and supply integration, comprehensive and in-depth procurement synergy mechanism are the successful experiences of China's emergency procurement. However, due to the temporary nature of the emergency procurement mechanism, strategic procurement planning, procurement management specialization, and procurement supply integration still need to be improved. The findings of this study further suggest that to improve public health and governance, it is pivotal to reconstruct the government procurement law to make it compatible with the emergency procurement and transform the government procurement system into a strategic procurement in a consistent and coherent way.

Is port state control influenced by the COVID-19? Evidence from inspection data.

Maritime transport plays a key role in global trade. The safeguard of maritime transport is the Port State Control (PSC) inspection implemented all over the world. The outbreak of the Coronavirus disease (COVID-19) in 2020 presents new and unprecedented impacts on global supply chains and the ports as well as the entire shipping industry. Various measures were adopted by the countries and regions to halt the spread of the pandemic, mainly by reducing face-to-face interactions. As PSC inspections involve getting onboard vessels and in-person communications between the inspectors and the crew, its procedure and results are highly likely to be influenced by the COVID-19. This study aims to explore whether, how, and why the global and regional PSC inspection statuses are influenced by the pandemic through analyzing real inspection data. Specifically, three general indicators, namely inspection number, average deficiency number per inspection, and detention rate, are considered. Moreover, a detailed and comprehensive analysis of the inspection data at the Hong Kong port is conducted, including the number of inspections conducted, the average deficiency number and detention rate, the types of inspections conducted and ships inspected, the detailed deficiency and detention conditions, the relationship between the local pandemic situation and the PSC inspection status, and regression analysis on the influencing factors on inspection outcome. It is found that the COVID-19 pandemic indeed has an impact on PSC. Meanwhile, pragmatic and flexible measures are adopted by the port states, and the PSC has always been acting as a 'safety net' to guarantee maritime safety, promote the marine environment, and protect the seafarers' rights even under the difficult times during the COVID-19 pandemic.

Effectiveness of a professional identity promotion strategy for nursing students during the COVID-19 pandemic: A quasi-experimental study.

AIM: To evaluate the effectiveness of a professional identity promotion strategy (PIPS) on nursing students' professional identity and resilience. METHODS: This study was a quasi-experimental study with a random cluster sample of 103 sophomore undergraduate nursing students. One hundred students answered the questionnaires at both baseline and follow-up (51 of 53 in the intervention group and 49 of 50 in the control group). Intervention and control groups underwent 5 months PIPS and standard professional education from May 2 to September 27, respectively. Participants completed the professional identity questionnaire for nursing students (PIQNS) and Connor-Davidson resilience scale (CD-RISC). Data were collected at baseline (T0), after the intervention (T1) and 3 months after the intervention (T2), and analyzed using the Chi-squared test, Fisher's exact test, and repeated-measures analysis of variance. RESULTS: There were no significant differences between the two groups (p > .05) regarding demographic questions, professional identity, or resilience at baseline (p > .05). Significant differences were found in professional identity between groups (p < .001), measurement times (p = .026), and in the interaction between groups and measurement times (p = .018) from T0 to T2. Significant differences were found in resilience between groups (p < .001), measurement times (p = .007), and in the interaction between groups and measurement times (p = .035) from T0 to T2. CONCLUSIONS: The PIPS program improved nursing students' professional identity and resilience. Further long-term effectiveness of the program needs to be tested with implementation through various forms of mobile technology.

Ports Opening for Seafarer Change during the COVID-19: Models and Applications

Countries around the world have tightened their border controls in response to the spread of COVID-19. Consequently, seafarers are prohibited from boarding or leaving ships at most ports, with few exceptions. This situation means that seafarers are highly likely to serve onboard vessels beyond their contracted shifts. Most seafarers are prone to depression because they have to spend long periods at sea away from family and friends, and, thus, banning crew changes will put their mental health further at risk. This will increase the likelihood of maritime accidents, thus jeopardizing global supply chains and ultimately exacerbating current hardships. To tackle this emergency, the International Maritime Organization and the European Commission have called on governments to coordinate efforts to designate ports for crew changes during the pandemic. This study aims to solve the crew change problem by using an integer linear programming model. In the sensitivity analysis section, we find that the number of opening ports for crew changes and the cost of crew changes decrease when the cost of opening ports increases. The results show governments will not invest in opening more ports when the cost of opening ports increases. However, the penalty increases when the number of open ports decreases, and the cost of opening ports increases. As the number of crew changes is decreasing, this leads to the penalty increasing, when the number of open ports decreases.

Comparative study on ct features of COVID-19 patients of imported and local in Gansu

Objective: To investigate the CT features and clinical features of coronavirus disease 2019(COVID-19) patients imported from abroad, China and infected locally.

Extreme risk spillover between chinese and global crude oil futures.

This paper investigates the risk spillover between China's crude oil futures and international crude oil futures by constructing upside and downside VaR connectedness networks. The findings show that China's crude oil futures behave as a net risk receiver in the global crude oil system, in which Brent and WTI play the leading roles in risk transmission in the system. The dynamic results indicate that the risk spillover between Chinese and international crude oil futures presents obvious time-varying characteristics and has risen sharply since the beginning of 2020, induced by the COVID-19 pandemic.

Impacts of transportation and meteorological factors on the transmission of COVID-19.

The ongoing pandemic of 2019 novel coronavirus disease (COVID-19) is challenging global public health response system. We aim to identify the risk factors for the transmission of COVID-19 using data on mainland China. We estimated attack rate (AR) at county level. Logistic regression was used to explore the role of transportation in the nationwide spread. Generalized additive model and stratified linear mixed-effects model were developed to identify the effects of multiple meteorological factors on local transmission. The ARs in affected counties ranged from 0.6 to 9750.4 per million persons, with a median of 8.8. The counties being intersected by railways, freeways, national highways or having airports had significantly higher risk for COVID-19 with adjusted odds ratios (ORs) of 1.40 (p = 0.001), 2.07 (p < 0.001), 1.31 (p = 0.04), and 1.70 (p < 0.001), respectively. The higher AR of COVID-19 was significantly associated with lower average temperature, moderate cumulative precipitation and higher wind speed. Significant pairwise interactions were found among above three meteorological factors with higher risk of COVID-19 under low temperature and moderate precipitation. Warm areas can also be in higher risk of the disease with the increasing wind speed. In conclusion, transportation and meteorological factors may play important roles in the transmission of COVID-19 in mainland China, and could be integrated in consideration by public health alarm systems to better prevent the disease.